Pharmachologic effect

The active ingredient of Lasix - Furosemide - has a diuretic effect by blocking the reabsorption of sodium and chloride in the ascending part of the loop of Henle. To a small extent Lasix acts on the convoluted tubules, this mechanism is not related to antialdosterone activity or inhibition of carbonic anhydrase. Lasix promotes the excretion of potassium, magnesium, calcium.

When Lasix administered intravenously, can reduce the blood pressure fast enough, the pressure in the pulmonary artery, and preload pressure in the left ventricle. The diuretic effect was observed already after 5 min., Reaching a maximum for half an hour, the duration of diuretic period is about 2 hours.
When administered diuretic effect of Lasix starts within the first hour, reaching a peak after 1.5-2 hours, the duration of the effective period of about 7 hours.
In the body Lasix (UK) metabolized and excreted primarily in the urine, in the form of compounds with glucuronic acid.

Indications

1.Otechny syndrome, which developed as a result of:
- Heart disease;
- Kidney disease;
- Liver disease;
- Acute left ventricular failure;
- Burn disease;
- Pre-eclampsia pregnancy (Lasix use is possible only after the restoration of the BCC).
2. Forced diuresis.
3. Combined therapy of hypertension.

Mode of application. Tips from the UK athletes

Dosing and dosing regimen should be set individually depending on the degree of violation of water and electrolyte balance, the value of glomerular filtration. Further dose adjustments required, depending on the severity of the patient's condition, the magnitude of diuresis. Usually the drug in the UK is administered in tablet form, but if this is not possible, or it comes to urgent conditions, the drug is administered intravenously, the introduction of Lasix should not be less than 1.5-2 minutes.

With an average degree of severity of edema syndrome Lasix an initial dose is 20-80 mg or 20-40 mg orally or intravenously intramuscularly, with little effect, the dose can be increased to 40 mg in the case of oral administration and 20 mg when administered as Lasix injection . Increasing the dose may not be earlier than 6-8 hours after taking an initial oral dose, and no earlier than 2 hours after parenteral administration. Dose adjustment takes place until adequate diuresis. Matched thus single dose can be administered once or twice a day. The maximum effect of Lasix occur if drug is given 2-4 times a week.
For children, the dose depends on the child's body weight and mode of administration of Lasix. The initial dose for oral administration is 2 mg / kg, the injection route of administration - 1 mg / kg. Then, may increase the dose to 2 mg / kg when administered orally and 1 mg / kg when administered parenterally. Increasing the dose may not be earlier than 6-8 hours after taking an initial oral dose, and no earlier than 2 hours after parenteral administration.

The combined treatment of hypertension, Lasix dose usually is 80 mg / day, preferably the daily dose be divided into two steps. A further increase in the dose is impractical, with little effect is to add other antihypertensive agents.
When pulmonary edema intravenously administered 40 mg, with little effect in 20 minutes can be entered even 20-40 mg.
During the forced diuresis, 20-40 mg Lasix added to a solution for intravenous infusion. Further Lasix dose may be adjusted depending on the water-electrolyte balance and the condition of the patient.

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